Test Catalog

Test ID: MUCN6    
Mucin 6, Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Aiding in subtyping intraductal papillary mucinous neoplasms (IPMN)

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Mucins are high-molecular weight glycoproteins produced by epithelial cells and can be divided into 2 families.  Mucin 6 (MUC6) is a large glycoprotein that plays a major role in the protection of the gastrointestinal tract and belongs to the family of secretory mucins. MUC6 is expressed in the cytoplasm/membrane of gastric pyloric epithelial cells. An immunopanel consisting of MUC1, MUC2, MUC5AC and MUC6 is useful in subtyping intraductal papillary mucinous neoplasms (IPMN).

Interpretation Provides information to assist in interpretation of the test results

The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut fresh.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Lau S, Weiss L, Chu P: Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites.  Am J Clin Pathol 2004;122:61-69

2. Pezhouh M, Park J: Gastric pyloric gland adenoma. Arch Pathol Lab Med 2015;139:823-826

3. Kwak H, Liu X, Allende D, et al: Interobserver variability in intraductal papillary mucinous neoplasm subtypes and application of their mucin immunoprofiles. Modern Pathology 2016;29:977-984

4. Kim D, Shin N, Kim G, et al: Mucin expression in gastric cancer. Arch Pathol Lab Med 2013;137:1047-1053

5. Castellano-Megias V, Ibarrola-de Andres C, Lopez-Alonso G, et al: Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas. World J Gastrointest Oncol 2014;6(9):311-324

6. Horinouchi M, Nagata K, Nakamura A, et al: Expression of different glycoforms of membrane mucin (MUC1) and secretory mucin (MUC2, MUC5AC and MUC6) in pancreatic neoplasms. Acta Histochem Cytochem 2003;36(5):443-453