Test Catalog

Test ID: PARVI    
Parvovirus Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Identification of parvovirus infection

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Parvovirus infection is implicated as a cause of hydrops fetalis and may result in spontaneous abortions. It has also been implicated in chronic hemolytic anemia. The virus is associated with erythema infectiosum (Fifth disease) in children and acute arthritis in adults.

Interpretation Provides information to assist in interpretation of the test results

This test includes only technical performance of the stain (no pathologist interpretation is performed). Mayo Clinic cannot provide an interpretation of tech only stains outside the context of a pathology consultation. If an interpretation is needed, refer to PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. All material associated with the case is required. Additional specific stains may be requested as part of the pathology consultation, and will be performed as necessary at the discretion of the Mayo pathologist.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Loughrey AC, O'Neill HJ, Coyle PV, DeLeys R: Identification and use of a neutralizing epitope of parvovirus B19 for the rapid detection of virus infection. J Med Virol 1993;39(2):97-100

2. Morey AL, Ferguson DJ, Fleming KA: Combined immunocytochemistry and non-isotopic in situ hybridization for the ultrastructural investigation of human parvovirus B19 infection. Histochem J 1995;27(1):46-53

3. Morey AL, Ferguson DJ, Fleming KA: Ultrastructural features of fetal erythroid precursors infected with parvovirus B19 in vitro: evidence of cell death by apoptosis. J Pathol 1993;169(2):213-220

4. Morey AL, O'Neill HJ, Coyle PV, Fleming KA: Immunohistological detection of human parvovirus B19 in formalin-fixed, paraffin-embedded tissues. J Pathol 1992 Feb;166(2):105-108