TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: FBUMT    
Bupropion and Metabolite, Serum

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Reporting Limit determined each analysis.

Units: ng/mL

Interpretation Provides information to assist in interpretation of the test results

Bupropion:

Maximum antidepressant response was observed at trough plasma concentrations of 50 – 100 ng/mL bupropion with virtually no response below 25 ng/mL.

 

Reported average bupropion peak plasma concentrations:

Adults: Single 100 mg IR – 120 +/- 10 ng/mL (Males):

150 +/- 10 ng/mL (Females)

Adults: Single 200 mg IR -220 +/- 20 ng/mL (Males):

270 +/- 20 ng/mL (Females)

Adults: Single 150 mg SR - 140 +/- 20 ng/mL

Juveniles: 100 mg/day SR for 2 weeks – 25 +/- 8 ng/mL

Juveniles: 200 mg/day SR for 2 weeks – 53 +/- 22 ng/mL

 

Specimens must be kept frozen. If specimens are not kept frozen, this may cause lower or negative values.

 

Hydroxybupropion:

8 adults (Age 22 – 42) taking thrice daily 100 mg normal release bupropion for 2 weeks had an average peak plasma concentration of 1000 +/- 70 ng/mL hydroxybupropion.

Juvenile patients taking once daily, extended release bupropion for two weeks had the following peak plasma concentrations:

100 mg/day (n = 11), 450 +/- 210 ng/mL hydroxybupropion

200 mg/day (n = 8), 710 +/- 350 ng/mL hydroxybupropion