TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: FAU3R    
Anti-U3 RNP Antibodies (Fibrillarin)

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

The U3-RNP (Fibrillarin) particle is thought to participate in the first step of preribosomal RNA processing. Anti-U3 RNP antibodies have been shown to be highly specific for patients with SSc. Anti-Fibrillarin (U3 RNP) antibodies are highly specific for diffuse SSc with a sensitivity of 4-10%. They are associated with isolated pulmonary arterial hypertension, myositis, renal and cardiac manifestations of SSc. 15% of IIM, mostly found in scleroderma/myositis overlap. Found in 4-10% of Diffuse SSc, <2% in Limited SSc, associated with isolated PAH, myositis, cardiac and renal involvement. More prevalent in African-Americans.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Negative