Test Catalog

Test ID: PCAB    
Parietal Cell Antibodies, IgG, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Negative: < or =20.0 Units

Equivocal: 20.1-24.9 Units

Positive: > or =25.0 Units 

Reference values apply to all ages.

Interpretation Provides information to assist in interpretation of the test results

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

The presence of immune complexes or other immunoglobulin aggregates in the patient specimen may cause an increased nonspecific binding and produce false-positive results in this assay.


A negative result does not rule out the presence of parietal cell antibodies; the concentration of antibody may be below the detection limit of the assay.


A positive result only indicates the presence of antibody to H(+)/K(+) ATPase and does not necessarily indicate the presence of autoimmune disease or other diseases.


The assay performance has not been established for pediatric patients.


Results of this assay should be used in conjunction with clinical findings and other serological tests.


The assay performance characteristics have not been established for matrices other than serum.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Toh BH, Van Driel IR, Gleeson PA: Pernicious anemia. N Eng J Med. 1997;337(20):1441-1448

2. Bizzaro N, Antico A: Diagnosis and classification of pernicious anemia. Autoimmun Rev. 2014;13(4-5):565-568

3. Toh BH: Pathophysiology and laboratory diagnosis of pernicious anemia. Immunol Res. 2017;65(1):326-330

4. Lenti MV, Rugge M, Lahner E, et al: Autoimmune gastritis. Nat Rev Dis Primers. 2020 Jul 9;6(1):56

6. Oo TH: Diagnostic difficulties in pernicious anemia. Discov Med. 2019;28(155):247-253