Test Catalog

Test Id : HOLDC

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Hematologic Disorders, Chromosome Hold, Varies

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Overview

Test Catalog

Useful For
Suggests clinical disorders or settings where the test may be helpful

Holding the bone marrow or peripheral blood specimen in the laboratory but delaying chromosome analysis while preliminary morphologic assessment is in process

Reflex Tests
Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test Id Reporting Name Available Separately Always Performed
CHRBM Chromosomes, Hematologic, BM Yes No
CHRHB Chromosomes, Hematologic, Blood Yes No
_ML20 Metaphases, 1-19 No, (Bill Only) No
_M25 Metaphases, 20-25 No, (Bill Only) No
_MG25 Metaphases, >25 No, (Bill Only) No
_STAC Ag-Nor/CBL Stain No, (Bill Only) No

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is designed to hold the specimen but delay chromosome preparation and analysis while preliminary morphologic assessment is in process.

 

Upon specimen receipt, the specimen will be held in the laboratory. Chromosome analysis will be performed unless the test is canceled (see Hold policy).

 

If the client notifies the laboratory that chromosome analysis is not necessary, this test will be reported as "Canceled." Chromosome analysis will not be performed but a processing fee will be charged.

 

If the client does not notify the laboratory that chromosome analysis is not needed (see Hold policy), this test will be reported as "Reflexed," and chromosome analysis will be performed. Depending on the specimen received, the appropriate reflex test will be performed. No processing fee will be assessed for this test as culture charges are included in the reflexed test.

 

Hold policy: The client must contact the Cytogenetics Laboratory at 800-533-1710 by 3 p.m. (Central time) no later than 2 business days after the specimen was collected to notify the lab not to proceed with chromosome analysis. If no notification is received by this time, chromosome analysis will be performed and charged. Weekend communication can be deferred until Monday.

Method Name
A short description of the method used to perform the test

Direct Preparation of Specimen

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Heme Chromosome Hold, B/BM

Aliases
Lists additional common names for a test, as an aid in searching

Bone marrow cell culture

Peripheral blood cell culture

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is designed to hold the specimen but delay chromosome preparation and analysis while preliminary morphologic assessment is in process.

 

Upon specimen receipt, the specimen will be held in the laboratory. Chromosome analysis will be performed unless the test is canceled (see Hold policy).

 

If the client notifies the laboratory that chromosome analysis is not necessary, this test will be reported as "Canceled." Chromosome analysis will not be performed but a processing fee will be charged.

 

If the client does not notify the laboratory that chromosome analysis is not needed (see Hold policy), this test will be reported as "Reflexed," and chromosome analysis will be performed. Depending on the specimen received, the appropriate reflex test will be performed. No processing fee will be assessed for this test as culture charges are included in the reflexed test.

 

Hold policy: The client must contact the Cytogenetics Laboratory at 800-533-1710 by 3 p.m. (Central time) no later than 2 business days after the specimen was collected to notify the lab not to proceed with chromosome analysis. If no notification is received by this time, chromosome analysis will be performed and charged. Weekend communication can be deferred until Monday.

Specimen Type
Describes the specimen type validated for testing

Varies

Ordering Guidance

This test does not apply to any fluorescence in situ hybridization (FISH) assays. If specimen is to be held for FISH testing, order HOLDF / Hematologic Disorders, Fluorescence In Situ Hybridization (FISH) Hold, Varies.

 

Chromosome analysis is not recommended for plasma cell neoplasms due to limited clinical utility.(1)

-If this test and a plasma cell FISH test (PCPDS / Plasma Cell Proliferative Disorder, High-Risk with Reflex Probes, Diagnostic FISH Evaluation, Bone Marrow MSMRT / Mayo Algorithmic Approach for Stratification of Myeloma and Risk-Adapted Therapy Report, Bone Marrow; or MFCDF / Myeloma Fixed Cell, High Risk with Reflex Probes, Diagnostic FISH Evaluation, Varies) are ordered concurrently, this test will be canceled and no processing fee will be charged.

-If a secondary myeloid neoplasm is suspected and both this test and a plasma cell FISH (PCPDS/MSMRT/MFCDF) are needed, contact the Cytogenetics Communication Team at 800-533-1710 before sending the specimen.

Shipping Instructions

Advise Express Mail or equivalent if not sent via courier service.

Necessary Information

Provide a reason for testing and bone marrow pathology report (if available) with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.

ORDER QUESTIONS AND ANSWERS

Question ID Description Answers
CG763 Reason for Referral
CG764 Specimen

Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Submit only 1 of the following specimens:

 

Preferred:

Specimen Type: Bone marrow

Container/Tube:

Preferred: Yellow top (ACD)

Acceptable: Green top (sodium heparin), lavender top (EDTA)

Specimen Volume: 1 to 2 mL

Collection Instructions: Invert several times to mix bone marrow.

 

Acceptable:

Specimen Type: Blood

Container/Tube:

Preferred: Yellow top (ACD)

Acceptable: Green top (sodium heparin), lavender top (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Invert several times to mix blood.

Forms

If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory

Blood: 2 mL

Bone marrow: 1 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)
Refrigerated

Useful For
Suggests clinical disorders or settings where the test may be helpful

Holding the bone marrow or peripheral blood specimen in the laboratory but delaying chromosome analysis while preliminary morphologic assessment is in process

Testing Algorithm
Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is designed to hold the specimen but delay chromosome preparation and analysis while preliminary morphologic assessment is in process.

 

Upon specimen receipt, the specimen will be held in the laboratory. Chromosome analysis will be performed unless the test is canceled (see Hold policy).

 

If the client notifies the laboratory that chromosome analysis is not necessary, this test will be reported as "Canceled." Chromosome analysis will not be performed but a processing fee will be charged.

 

If the client does not notify the laboratory that chromosome analysis is not needed (see Hold policy), this test will be reported as "Reflexed," and chromosome analysis will be performed. Depending on the specimen received, the appropriate reflex test will be performed. No processing fee will be assessed for this test as culture charges are included in the reflexed test.

 

Hold policy: The client must contact the Cytogenetics Laboratory at 800-533-1710 by 3 p.m. (Central time) no later than 2 business days after the specimen was collected to notify the lab not to proceed with chromosome analysis. If no notification is received by this time, chromosome analysis will be performed and charged. Weekend communication can be deferred until Monday.

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Conventional chromosome analysis is the gold standard for identification of the common, recurrent chromosome abnormalities for most hematologic malignancies. Based on morphologic review of the bone marrow or peripheral blood specimen by a hematopathologist, a determination of additional appropriate testing can be made. If the specimen does not show evidence of malignancy, chromosome analysis may not be necessary. Depending on the diagnosis, fluorescence in situ hybridization assays may also be more informative.

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Not applicable

Interpretation
Provides information to assist in interpretation of the test results

If notified by the client, this test may be canceled, and a processing fee assessed.

 

If no notification to cancel testing is received, this test will be reported as "reflexed for chromosome analysis" and depending on the specimen received, CHRBM / Chromosome Analysis, Hematologic Disorders, Bone Marrow or CHRHB / Chromosome Analysis, Hematologic Disorders, Blood will be performed, and an interpretive report provided.

Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Clinical Reference
Recommendations for in-depth reading of a clinical nature

1. Mellors PW, Binder M, Ketterling RH, et al. Metaphase cytogenetics and plasma cell proliferation index for risk stratification in newly diagnosed multiple myeloma. Blood Adv. 2020;4(10):2236-2244

Method Description
Describes how the test is performed and provides a method-specific reference

The specimen will be held in the laboratory while preliminary morphologic assessment is in process to determine if chromosome analysis is appropriate. If needed, cell culture and chromosome analysis will be performed.

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Sunday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

7 to 10 days

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

4 weeks

Performing Laboratory Location
Indicates the location of the laboratory that performs the test

Rochester

Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their account representative. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

Not Applicable

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

See Individual Components

LOINC® Information
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.

Test Id Test Order Name Order LOINC Value
HOLDC Heme Chromosome Hold, B/BM No LOINC Needed
Result Id Test Result Name Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
52290 Result Summary 50397-9
52292 Interpretation 69965-2
CG763 Reason for Referral 42349-1
CG764 Specimen 31208-2
52293 Source 31208-2
55267 Requested FISH Test 48767-8
52295 Method 85069-3
54639 Additional Information 48767-8
52296 Released by 18771-6

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | PHP Pdf | CMS Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports