Assessing muscle damage from any cause
Latex Particle-Enhanced Immunoturbidometric Assay
Myoglobin, Serum
Serum
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
0.5 mL
Gross hemolysis | Reject |
Gross lipemia | Reject |
Gross icterus | Reject |
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 14 days | |
Frozen | 14 days |
Assessing muscle damage from any cause
Myoglobin is a heme protein found in smooth and skeletal muscles. Serum myoglobin reflects a balance between intravascular release of myoglobin from muscle and renal clearance.
Previously serum myoglobin had been advocated as a sensitive marker for early acute myocardial injury (eg, acute myocardial infarction: AMI). However, more recent studies indicate that other newer markers (eg, troponin) provide superior diagnostic utility in detecting early myocardial injury.
Elevation of serum myoglobin may occur as a result of muscle trauma, resuscitation, myopathies, AMI, shock, strenuous body activity, or decreased elimination during renal insufficiency. Extreme elevations occur in rhabdomyolysis.
< or =90 mcg/L
Elevated myoglobin levels are seen in conditions of acute muscle injury.
Elevation is nonspecific for acute myocardial infarction. The test is of no value in this regard in the presence of renal failure, rhabdomyolysis, extensive trauma, acute peripheral vascular occlusion, or after seizures.
Serum levels rise in renal insufficiency.
In very rare cases, gammopathy, in particular type IgM (Waldenstrom macroglobulinemia), may cause unreliable results.
Results are unreliable in lipemic serum; specimens that cannot be cleared by ultracentrifugation will be rejected.
1. Lamb EJ, Jones GRD: Kidney functions tests. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:489
2. Cappenllini MD, Lo SF, Swinkels DW. Hemoglobin, iron, bilirubin. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:747
3. Varki AP, Roby DS, Watts H, Zatuchni J: Serum myoglobin in acute myocardial infarction: a clinical study and review of the literature. Am Heart J. 1978;96:680-688
4. Kallner A, Sylven C, Brodin U, et al: Early diagnosis of acute myocardial infarction. A comparison between chemical predictors. Scand J Clin Lab Invest. 1989;49:633-639
Particle-enhanced immunoturbidimetric assay. Latex-bound antimyoglobin antibodies react with antigen in the sample to form an antigen/antibody complex that after agglutination can be determined turbidimetrically.(Package insert: Tina-quant Myoglobin Gen 2. Roche Diagnostics; V9.0. 01/2017)
Monday through Sunday
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.
83874
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
MYGLS | Myoglobin, S | 2639-3 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
MYGLS | Myoglobin, S | 2639-3 |