Test Catalog

Test ID: RBCME    
Red Blood Cell Membrane Evaluation, Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

Investigation of suspected red cell membrane disorders such as hereditary spherocytosis or hereditary pyropoikilocytosis

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
FRAGOOsmotic FragilityYes, (Order FRAG)Yes
SCTRLShipping Control VialNoYes
HSEVSpherocytosis InterpretationNoYes
BND3Band 3 Fluorescence Staining, RBCNoYes
SMPBPeripheral Blood Smear ReviewNoYes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Osmotic fragility and eosin-5-maleimide (EMA) binding (Band3) flow cytometry testing will always be performed. A normal shipping control is necessary to exclude false-positive results due to preanalytical artifact. Testing will be canceled if no shipping control is received or if the shipping control is abnormal. A consultative interpretation will be provided.


See Benign Hematology Evaluation Comparison in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

HSEV: Consultative Interpretation

FRAGO: Osmotic Lysis

BND3: Flow Cytometry

SMPB: Consultant Review

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

RBC Membrane Evaluation, B

Aliases Lists additional common names for a test, as an aid in searching

Band 3
EMA Binding
Osmotic Fragility
RBC membrane
Hereditary spherocytosis
Hereditary pyropoikilocytosis