Test Catalog

Test ID: HHLP    
AudioloGene Hereditary Hearing Loss Panel, Varies

Method Description Describes how the test is performed and provides a method-specific reference

Next-generation sequencing (NGS) and/or Sanger sequencing is performed to test for the presence of a sequence variant in all genes analyzed. Additionally, digital droplet polymerase chain reaction (ddPCR) is performed to test for 3 mitochondrial variants included in this panel.


Finally, NGS or multiplex ligation-dependent probe amplification (MLPA) is used to test for the presence of large deletions and duplications in the majority of genes.  There may be regions of genes that cannot be effectively amplified for sequencing or large deletion and duplication analysis as a result of technical limitations of the assay, including regions of homology, high guanine-cytosine (GC)-rich content, and repetitive sequences.  


MLPA, PCR, qPCR, array comparative genomic hybridization (aCGH) or Sanger sequencing may be used to confirm alterations detected by NGS when appropriate.(Unpublished Mayo method)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.

Performed weekly; Varies

Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.

10 weeks

Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Clinic Laboratories until the release of the test result

12 weeks

Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

Whole Blood: 2 weeks (if available) Extracted DNA: Indefinitely

Performing Laboratory Location Indicates the location of the laboratory that performs the test