The qualitative detection and identification of prescription or over-the-counter drugs frequently found in drug overdose or used with a suicidal intent
Providing, when possible, the identification of all drugs present
This test is not useful for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, and amphetamine type stimulants.
This test is not useful for the assessment of therapeutic compliance.
This test is not intended for use in employment-related testing.
Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was under the control of personnel involved with testing the specimen at all times; this control implies that the opportunity for specimen tampering would be limited.
Test Id | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
COCH | Chain of Custody Processing | No | Yes |
Gas Chromatography-Mass Spectrometry (GC-MS)
acetaminophen
amitriptyline
amobarbital
bupropion
butabarbital
butalbital
caffeine
carbamazepine
carisoprodol
chlorpheniramine
chlorpromazine
citalopram
clomipramine
clozapine
codeine
cyclobenzaprine
dextromethorphan
diazepam
diphenhydramine
doxepin
doxylamine
fentanyl
fluoxetine
guaifenesin
ibuprofen
imipramine
lamotrigine
levetiracetum
lidocaine
mephobarbital
meperidine
meprobamate
metaxalone
methadone
methsuximide
methylphenidate
midazolam
mirtazepine
naproxen
nordiazepam
nortriptyline
oxcarbazepine metabolite
pentobarbital
phenobarbital
primidone
promethazine
propofol
salicylate
secobarbital
sertraline
strychnine
theophylline
thioridazine
topiramate
tramadol
trazodone
trimipramine
venlafaxine
zaleplon
zolpidem
Urine
If urine creatinine is required or adulteration of the sample is suspected, also order, ADLTX / Adulterants Survey, Chain of Custody, Random, Urine.
Supplies: Chain-of-Custody Kit (T282) containing the specimen containers, seals, and documentation is required.
Specimen Volume: 30 mL
Collection Instructions: Collect a random specimen in the container provided, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.
Additional Information
1. Submitting less than 30 mL will compromise the ability to perform all necessary testing.
2. See Emergency/Overdose.
1. Chain of Custody Request is included in the Chain-of-Custody Kit (T282).
2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.
1.1 mL
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Refrigerated (preferred) | 14 days | |
Frozen | 14 days | ||
Ambient | 3 hours |
The qualitative detection and identification of prescription or over-the-counter drugs frequently found in drug overdose or used with a suicidal intent
Providing, when possible, the identification of all drugs present
This test is not useful for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, and amphetamine type stimulants.
This test is not useful for the assessment of therapeutic compliance.
This test is not intended for use in employment-related testing.
Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was under the control of personnel involved with testing the specimen at all times; this control implies that the opportunity for specimen tampering would be limited.
This test looks for a broad spectrum of prescription and over-the-counter (OTC) drugs. It is designed to detect drugs that have toxic effects, as well as known antidotes or active therapies that a clinician can initiate to treat the toxic effect. The test is intended to help physicians manage an apparent overdose or intoxicated patient, to determine if a specific set of symptoms might be due to the presence of drugs, or to evaluate a patient who might be abusing these drugs intermittently. This test is not appropriate for drugs of abuse or illicit drug testing, including benzodiazepines, opioids, barbiturates, cocaine, and amphetamine type stimulants.
Drugs of toxic significance that are not detected by this test are: digoxin, lithium, and many drugs of abuse or illicit drugs, some benzodiazepines, and some opiates. For these drugs, see Mayo Clinic Laboratories' drug abuse surveys, drug screens, or individual tests.
Chain of custody is a record of the disposition of a specimen to document the personnel who collected it, who handled it, and who performed the analysis. When a specimen is submitted in this manner, analysis will be performed in such a way that it will withstand regular court scrutiny.
See Emergency/Overdose for detection limits for drugs detected in this test.
Drugs detected are presumptive. Additional testing may be required to confirm the presence of any drugs detected.
The drugs that can be detected by this test are listed in Emergency/Overdose.
A detailed discussion of each drug detected is beyond the scope of this text. Each report will indicate the drugs identified. If a clinical interpretation is required, request a Clinical and Forensic Toxicology Lab consult (Mayo Clinic patients) or contact Mayo Laboratory Inquiry (Mayo Clinic Laboratories clients).
No significant cautionary statements.
1. Langman LJ, Bechtel LK, Meier BM, Holstege C: Clinical toxicology. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:1294
2. Baselty RC: Disposition of Toxic Drugs and Chemicals in Man. 10th ed. Biomedical Publications, 2014
Screening is by gas chromatography-mass spectroscopy.(Unpublished Mayo method)
Monday through Friday
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.
80307
Test Id | Test Order Name | Order LOINC Value |
---|---|---|
PDSUX | Drug Scrn, Prescription/OTC, CoC, U | 12286-1 |
Result Id | Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
---|---|---|
36235 | Drugs detected: | 12286-1 |
36236 | Suspect Drug | 12286-1 |
36237 | Chain of Custody | 77202-0 |