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Test Catalog

Test ID: TDP    
Thiamine (Vitamin B1), Whole Blood

Useful For Suggests clinical disorders or settings where the test may be helpful

Assessment of thiamine deficiency

 

Measuring thiamine levels in patients with behavioral changes, eye signs, gait disturbances, delirium, and encephalopathy; or in patients with questionable nutritional status, especially those who appear at risk and who also are being given insulin for hyperglycemia

Highlights

-Whole blood thiamine testing is superior to currently available alternative tests for assessing thiamine status. Serum or plasma thiamine testing suffers from poor sensitivity and specificity, and less than 10% of blood thiamine is contained in plasma.

-Thiamine diphosphate (TDP) is the active form of thiamine and is most appropriately measured to assess thiamine status. Thiamine diphosphate in circulating blood is present in erythrocytes, but is undetectable (present in very low levels) in plasma or serum.

-LC-MS/MS analysis of TDP in whole blood is the most sensitive, specific, and precise method for determining the nutritional status of thiamine and is a reliable indicator of total body stores.

-This assay specifically targets and quantitates the active form of thiamine, TDP, as an indicator of thiamine status.

Method Name A short description of the method used to perform the test

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Thiamin (Vitamin B1), WB

Aliases Lists additional common names for a test, as an aid in searching

Thiamin Diphosphate (TDP)
Thiamin Pyrophosphate (TPP)
Thiamine
Vitamin B1
VITB1
B1, Vitamin